폴리아네톨 설포네이트 나트륨(SPS)이란 무엇인가요?

I. What is Sodium Polyanethol Sulfonate (SPS)?

Sodium Polyanethol Sulfonate (SPS, CAS 55963-78-5) is a crucial chemical additive widely used in clinical microbiology and blood culture systems.

It exists as a white or light-yellow crystalline powder and combines the following two core functions: Anticoagulant and Growth Promoter / Antimicrobial Neutralizer.

It is precisely this unique “dual functionality” that makes it an indispensable fundamental component in modern blood culture systems.

II. What is the Mechanism of Action of SPS in Blood Cultures? (Core Principle Analysis)

Sodium Polyanethol Sulfonate improves the blood culture environment and increases the positive detection rate of pathogenic microorganisms through a “Triple Synergistic Mechanism.”

1. Antibiotic Neutralization
SPS can neutralize certain antibiotics present in the blood (e.g., aminoglycosides), reducing the risk of false-negative results.

2. Inhibition of Host Immune Factors
SPS exerts an inhibitory effect on various innate immune components, including:

· Neutralizing Lysozyme
· Inhibiting Leukocyte Phagocytosis
· Interfering with Complement System Activation

These actions collectively create a more favorable microenvironment for bacterial proliferation.

3. Prevention of Blood Coagulation (Anticoagulation Mechanism)
SPS enhances the activity of Antithrombin III, inhibiting:

· Thrombin
· Coagulation Factor Xa

This ensures the blood sample maintains liquid stability throughout the culture process.

III. Main Application Areas of SPS

1. Core Additive in Blood Culture Systems
SPS is a key ingredient in most commercial blood culture bottles (including anaerobic bottles and dual-bottle culture systems).

Its primary functions include:

· Inhibiting natural antimicrobial substances present in the blood itself.
· Improving the positive detection rate of bacteria and fungi.
· Reducing the occurrence of false-negative results.

2. Specialized Anticoagulant
Based on its defined anticoagulant mechanism, SPS is also used in:

· Certain in vitro experiments.
· Specific clinical tests.
· Microbiology research scenarios.
…where maintaining blood sample liquidity and microbial viability is required.

IV. How to Evaluate and Select a Suitable SPS Product?

When selecting SPS, the following factors should be prioritized:

1. Purity Level
Affects anticoagulant performance and microbial detection efficacy.

2. Particle Size
Related to dissolution rate and ease of use.

3. Compatibility with Blood Culture Media
Ensures no antagonistic effects with the culture medium, agar, or in-bottle formulation.

4. Supply Reliability
Blood culture is a clinical necessity, placing high demands on a supplier’s stability.

V. Summary: Why is SPS Crucial for Blood Cultures?

Sodium Polyanethol Sulfonate (SPS) significantly enhances the detection efficiency of pathogens in bloodstream infections through its triple action of Anticoagulation + Neutralizing Antimicrobial Factors + Inhibiting the Immune System. It is an irreplaceable core component of modern blood culture bottles.

It holds critical value in the diagnosis of major infectious diseases such as Sepsis and Bacteremia.

For SPS products and technical support, 창사 유텅 신소재 유한공사 has long been focused on the field of blood culture additives, offering:

· High-Purity SPS
· Various Grades of Blood Culture Additives
· Technical Consultation and Formulation Optimization Solutions